바카라 사이트 쿠폰 신경 줄기 세포의 유지에서 출생의 중요성 발견
바카라 사이트 쿠폰 신경 줄기 세포의 유지에서 출생의 중요성 발견
바카라 사이트 쿠폰-induced alteration of glutamine metabolism is required for the acquisition of quiescence and long-term maintenance of postnatal neural stem cells. Preterm 바카라 사이트 쿠폰 impairs this cellular process, leading to decreased postnatal neurogenesis.
바카라 사이트 쿠폰-induced alteration of glutamine metabolism is required for the acquisition of quiescence and long-term maintenance of postnatal neural stem cells. Preterm 바카라 사이트 쿠폰 impairs this cellular process, leading to decreased postnatal neurogenesis.
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바카라 사이트 쿠폰 is one of the most significant life events for animals. The transition from the intrauterine to the extrauterine environment causes various metabolic changes in individuals. Despite its significance, the role of 바카라 사이트 쿠폰 in the developmental process remains incompletely understood. In the adult mammalian brain, NSCs are retained in the ventricular-subventricular zone(V-SVZ), where they continue to generate new neurons. The majority of postnatal NSCs are maintained in a quiescent state, enabling their long-term maintenance. In various tissues, metabolic profiles of the stem cell niche and of the stem cells themselves play a critical role in determining whether the cells remain quiescent or transition to an active, differentiated state. However, how 바카라 사이트 쿠폰-associated metabolic changes affect the fate of tissue stem cells, especially NSCs, is largely unknown.
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“To understand the role of 바카라 사이트 쿠폰 in the maintenance of quiescent NSCs, we evaluated the effects of preterm 바카라 사이트 쿠폰 on postnatal neurogenesis,” Sawamoto said.
Next, the team histologically analyzed the changes in the neurogenic activity of RG. They showed that RG transiently enter a neurogenic state via mTORC1 signaling in preterm 바카라 사이트 쿠폰 mice. However, they also found that neurogenesis at the young-adult stage was decreased due to depletion of the NSC pool in preterm 바카라 사이트 쿠폰 mice. Furthermore, they analyzed human autopsy brains and found that postnatal neurogenesis in the V-SVZ is decreased by preterm 바카라 사이트 쿠폰 not only in mice but also in humans.
“Considering that 바카라 사이트 쿠폰 neurogenesis plays an important role in brain development and plasticity in humans, the reduction in 바카라 사이트 쿠폰 neurogenesis may be a cause of worse neurodevelopmental outcome in preterm infants,” Kawase said.
Finally, to examine the role of 바카라 사이트 쿠폰-induced upregulation of Glul in RG, they generated Glul-knockdown and -overexpression lentiviruses and infected them to RG in vivo. Their experiments demonstrated that sufficient upregulation of Glul in RG at an appropriate time of 바카라 사이트 쿠폰 is critical for the maintenance of quiescent NSCs.
“We have uncovered the significance of 바카라 사이트 쿠폰 in the maintenance of quiescent NSCs. Considering that glutamine metabolism also regulates the functions of tissue stem cells other than NSCs, our findings enhance our understanding of the pivotal role of 바카라 사이트 쿠폰 in tissue homeostasis and regenerative capacities,” Sawamoto commented.
The full findings of the study are published in the Science Advances.
Article title: Significance of 바카라 사이트 쿠폰 in the maintenance of quiescent neural stem cells. DOI:10.1126/sciadv.adn6377
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바카라 사이트 쿠폰 is one of the most significant life events for animals. The transition from the intrauterine to the extrauterine environment causes various metabolic changes in individuals. Despite its significance, the role of 바카라 사이트 쿠폰 in the developmental process remains incompletely understood. In the adult mammalian brain, NSCs are retained in the ventricular-subventricular zone(V-SVZ), where they continue to generate new neurons. The majority of postnatal NSCs are maintained in a quiescent state, enabling their long-term maintenance. In various tissues, metabolic profiles of the stem cell niche and of the stem cells themselves play a critical role in determining whether the cells remain quiescent or transition to an active, differentiated state. However, how 바카라 사이트 쿠폰-associated metabolic changes affect the fate of tissue stem cells, especially NSCs, is largely unknown.
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“To understand the role of 바카라 사이트 쿠폰 in the maintenance of quiescent NSCs, we evaluated the effects of preterm 바카라 사이트 쿠폰 on postnatal neurogenesis,” Sawamoto said.
Next, the team histologically analyzed the changes in the neurogenic activity of RG. They showed that RG transiently enter a neurogenic state via mTORC1 signaling in preterm 바카라 사이트 쿠폰 mice. However, they also found that neurogenesis at the young-adult stage was decreased due to depletion of the NSC pool in preterm 바카라 사이트 쿠폰 mice. Furthermore, they analyzed human autopsy brains and found that postnatal neurogenesis in the V-SVZ is decreased by preterm 바카라 사이트 쿠폰 not only in mice but also in humans.
“Considering that 바카라 사이트 쿠폰 neurogenesis plays an important role in brain development and plasticity in humans, the reduction in 바카라 사이트 쿠폰 neurogenesis may be a cause of worse neurodevelopmental outcome in preterm infants,” Kawase said.
Finally, to examine the role of 바카라 사이트 쿠폰-induced upregulation of Glul in RG, they generated Glul-knockdown and -overexpression lentiviruses and infected them to RG in vivo. Their experiments demonstrated that sufficient upregulation of Glul in RG at an appropriate time of 바카라 사이트 쿠폰 is critical for the maintenance of quiescent NSCs.
“We have uncovered the significance of 바카라 사이트 쿠폰 in the maintenance of quiescent NSCs. Considering that glutamine metabolism also regulates the functions of tissue stem cells other than NSCs, our findings enhance our understanding of the pivotal role of 바카라 사이트 쿠폰 in tissue homeostasis and regenerative capacities,” Sawamoto commented.
The full findings of the study are published in the Science Advances.
Article title: Significance of 바카라 사이트 쿠폰 in the maintenance of quiescent neural stem cells. DOI:10.1126/sciadv.adn6377
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© 바카라 사이트 쿠폰 City University 의료 과학 대학원
바카라 사이트 쿠폰 Neural Stem Cell
This image shows a postnatal neural stem cell (NSC) in the ventricular-subventricular zone. The majority of postnatal NSCs are maintained in a quiescent state, allowing for long-term maintenance. 바카라 사이트 쿠폰-induced alterations in glutamine metabolism are required for postnatal NSCs to acquire quiescence.
참조
Journal：Science Advances
DOI：10.1126/sciadv.adn6377
Journal：Science Advances
DOI：10.1126/sciadv.adn6377
저자
Kazunobu Sawamoto
Kazunobu Sawamoto