글리 칸 성숙을위한 바카라 사이트 쿠폰 통제
글리 칸 성숙을위한 바카라 사이트 쿠폰 통제
요약 텍스트
A new technology enhances critical modifications of glycoprotein glycans, specifically galactosylation and sialylation, by adding a “passport sequence” that promotes efficient transport through the secretory pathway. This approach improves the quality and efficiency of therapeutic glycoproteins, advancing the development of high-quality biopharmaceuticals.
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The study focuses on a short, 10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking of glycoproteins through the secretory pathway. When attached to target proteins, this sequence enhances their interactions with glycosylation enzymes in the Golgi apparatus, leading to significantly increased galactosylation and sialylation—critical modifications that impact protein stability and efficacy.
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검색
A new technology enhances critical modifications of glycoprotein glycans, specifically galactosylation and sialylation, by adding a “passport sequence” that promotes efficient transport through the secretory pathway. This approach improves the quality and efficiency of therapeutic glycoproteins, advancing the development of high-quality biopharmaceuticals.
전체 텍스트
검색
The study focuses on a short, 10-amino-acid sequence called the "passport sequence," which facilitates the efficient trafficking of glycoproteins through the secretory pathway. When attached to target proteins, this sequence enhances their interactions with glycosylation enzymes in the Golgi apparatus, leading to significantly increased galactosylation and sialylation—critical modifications that impact protein stability and efficacy.
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바카라 사이트 쿠폰 시퀀스 태그 Glycan 성숙을 촉진
바카라 사이트 쿠폰 서열 (PS) 태그가 붙은 당 단백질은화물 수송 수신기에 의해 인식되고, 그 이후의 galactosylation 및 후속 Siallation은 NucB1에 대한 갈 락토 실 트랜스퍼 라제에 의해 약속된다.
참조
Journal：iScience
DOI：10.1016/j.isci.2024.111457
저자
Hirokazu Yagi and Koichi Kato
Journal：iScience
DOI：10.1016/j.isci.2024.111457
저자
Hirokazu Yagi and Koichi Kato