2019 년 11 월 5 일
Currently, best-characterized indicators for Alzheimer's disease (바카라 커뮤니티) diagnosis are the decreased levels of amyloid β-protein 42 and increased levels of phosphorylated tau in cerebrospinal fluid (CSF). The positron emission tomography (PET) imaging with Pittsburgh compound B (PiB) is also used in 바카라 커뮤니티 diagnosis by visualizing amyloid deposition in the brain. Because these methods are invasive or expensive, less invasive and easily detectable blood biomarkers are required. Because our previous study showed that flotillin release, a marker of exosomes, was attenuated by Aβ, we designed a present study to determine whether flotillin level could be reduced in CSF and/or serum of patients with 바카라 커뮤니티.
In this study, we analyzed flotillin levels in CSF and serum of non-바카라 커뮤니티 controls, patients with 바카라 커뮤니티 and mild cognitive impairment (MCI) by western blotting. Flotillin levels in cerebroventricular fluid (CVF) and serum of 바카라 커뮤니티, vascular dementia (VD), and non-바카라 커뮤니티 autopsy cases are also analyzed. Flotillin levels significantly decreased in the CSF and serum of 바카라 커뮤니티 patients compared with those of non-바카라 커뮤니티 controls, respectively. Moreover, in patients with MCI due to 바카라 커뮤니티 determined by PiB-PET, CSF and serum flotillin levels significantly decreased compared with those of patients with MCI due to non-바카라 커뮤니티. Flotillin levels remained unchanged in CVF and serum of autopsy cases diagnosed as VD. Serum flotillin level is negatively associated with brain amyloid deposition indicated as PiB uptake. These results demonstrate that serum flotillin level can serve as one of the blood markers for estimation of brain amyloid deposition and early diagnosis of 바카라 커뮤니티.